About City of Hope
City of Hope, an innovative biomedical research, treatment and
educational institution with over 6000 employees, is dedicated to
the prevention and cure of cancer and other life-threatening
diseases and guided by a compassionate, patient-centered
Founded in 1913 and headquartered in Duarte, California, City of
Hope is a remarkable non-profit institution, where compassion and
advanced care go hand-in-hand with excellence in clinical and
scientific research. City of Hope is a National Cancer Institute
designated Comprehensive Cancer Center and a founding member of the
National Comprehensive Cancer Network, an alliance of the nation's
leading cancer centers that develops and institutes standards of
care for cancer treatment.
Are you passionate about immune signaling? Do you want to
innovate at the interface between basic biology and clinical
application, where cancer biology and immunology intersect? Are you
passionate about making a difference in patients' lives?
The Leo Wang Lab at City of Hope is hiring a staff scientist
with expertise and interest in fundamental immune signaling to join
our group in the Department of Immunooncology. We couple
protein-focused molecular techniques (mass spectrometry, capillary
Western blot, flow cytometry, CyTOF) with in vitro and in vivo
disease models to define the molecular basis of chimeric antigen
receptor (CAR) signaling and activation. We correlate these
fundamental proteomic pathways with their functional consequences,
and use this information to aid in the rational design of
solid-tumor targeted CAR constructs with improved persistence and
potency. To learn more about our research, visit:
Scientists with a Ph.D. or equivalent degree and 5 years of
postdoctoral experience are encouraged to apply. The ideal
candidate will be bright, ambitious, diligent, meticulous,
collaborative, and creative. Core competencies include cell and
molecular biology, flow cytometry, protein biochemistry, and mouse
work. Computational competency (R, Python) is a plus. Candidates
need not wish to pursue a tenure-track academic faculty position,
but must be able to design and execute scientific projects
independently. Successful candidates must be able to generate data
quickly and carefully, synthesize it to design new experiments, and
communicate findings efficiently in manuscript form.
Our lab is well-resourced, with research support from the NIH
and multiple foundations. Staff scientists will not be required to
obtain their own funding. Our lab and institution are also highly
collaborative, and staff scientists will be required to be able to
work well with others. Additionally, those who show an aptitude for
mentorship will be given the opportunity to supervise junior
Key Responsibilities include:
- Design and lead projects focused on CAR T cell signaling in
multiple model systems, using canonical TCR signaling as a
- Coordinate lab tasks and operations among multiple lab members,
including ordering, inventory, and other essential lab
- Keep detailed and accurate logs of experimental design and
primary data, analysis, and synthesis.
- Prepare data presentations and manuscripts for
- Initiate and maintain collaborations with other labs.
- Travel to meetings to represent the lab and to present new
Basic education, experience and skills required for
- Ability to be independently productive, meticulous, and
- Ability to develop cohesive team relationships and manage
- Extensive prior experience in immunology or a closely related
- Good English oral and written communication skills; must be
able to prepare scientific manuscripts.
- Ability to respond effectively to constructive feedback.
Preferred education experience and skills:
- Programming experience (R, Python), preferred.
City of Hope is committed to creating a diverse environment and
is proud to be an equal opportunity employer. All qualified
applicants will receive consideration for employment without regard
to race, religion, color, national origin, sex, sexual orientation,
gender identity, age, status as a protected veteran, or status as a
qualified individual with disability.
- Posting Date: Mar 23, 2021
- Job Field: Research
- Employee Status: Regular
- Shift: Day Job